Epigenetic changes associated with disease progression in a mouse model of childhood allergic asthma

• Main Authors: Adam Collison (Author), Jessica S. Siegle (Author), Nicole G. Hansbro (Author), Chau-To Kwok (Author), Cristan Herbert (Author), Joerg Mattes (Author), Megan Hitchins (Author), Paul S. Foster (Author), Rakesh K. Kumar (Author)
• Format: Book
• Published: The Company of Biologists, 2013-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Development of asthma in childhood is linked to viral infections of the lower respiratory tract in early life, with subsequent chronic exposure to allergens. Progression to persistent asthma is associated with a Th2-biased immunological response and structural remodelling of the airways. The...