Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT10

• Main Authors: Naoko Ohtsu (Author), Ryuichi Ohgaki (Author), Chunhuan Jin (Author), Minhui Xu (Author), Hiroki Okanishi (Author), Ryo Takahashi (Author), Akiko Matsui (Author), Wataru Kishimoto (Author), Naoki Ishiguro (Author), Yoshikatsu Kanai (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

OAT10 (SLC22A13) is a transporter highly expressed in renal tubules and transporting organic anions including nicotinate, β-hydroxybutyrate, p-aminohippurate, and orotate. In transport assays using Xenopus oocytes and HEK293 cells, we found that apparent substrate selectivity of OAT10 was different...