Impacts of NaHCO₃ on β-Lactam Binding to PBP2a Protein Variants Associated with the NaHCO₃-Responsive versus NaHCO₃-Non-Responsive Phenotypes

• Main Authors: Selvi C. Ersoy (Author), Liana C. Chan (Author), Michael R. Yeaman (Author), Henry F. Chambers (Author), Richard A. Proctor (Author), Kevin C. Ludwig (Author), Tanja Schneider (Author), Adhar C. Manna (Author), Ambrose Cheung (Author), Arnold S. Bayer (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) regulates resistance to β-lactams via preferential production of an alternative penicillin-binding protein (PBP), PBP2a. PBP2a binds many β-lactam antibiotics with less affinity than PBPs which are predominant in methicillin-susce...