Psoralen Induced Liver Injury by Attenuating Liver Regenerative Capability

• Main Authors: Wang Zhou (Author), Xi Chen (Author), Guolin Zhao (Author), Dengqiu Xu (Author), Zhenzhou Jiang (Author), Luyong Zhang (Author), Tao Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Psoralen is a major component of the common traditional Chinese medicine Fructus Psoraleae (FP). In this study, we focused on psoralen to explore FP-induced hepatotoxicity and the underlying mechanisms. The acute oral median lethal dose of psoralen in ICR mice was determined to be 1,673 mg/kg. C57BL...