Psoralen Induced Liver Injury by Attenuating Liver Regenerative Capability

• Hlavní autoři: Wang Zhou (Autor), Xi Chen (Autor), Guolin Zhao (Autor), Dengqiu Xu (Autor), Zhenzhou Jiang (Autor), Luyong Zhang (Autor), Tao Wang (Autor)
• Médium: Kniha
• Vydáno: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Psoralen is a major component of the common traditional Chinese medicine Fructus Psoraleae (FP). In this study, we focused on psoralen to explore FP-induced hepatotoxicity and the underlying mechanisms. The acute oral median lethal dose of psoralen in ICR mice was determined to be 1,673 mg/kg. C57BL...