Piperlongumine Is an NLRP3 Inhibitor With Anti-inflammatory Activity

• Main Authors: Jie Shi (Author), Yang Xia (Author), Huihong Wang (Author), Zhongjie Yi (Author), Ruoruo Zhang (Author), Xiufeng Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Piperlongumine (PL) is an alkaloid from Piper longum L. with anti-inflammatory and antitumor properties. Numerous studies have focused on its antitumor effect. However, the underlying mechanisms of its anti-inflammation remain elusive. In this study, we have found that PL is a natural inhibitor of N...