IgA autoantibodies directed against self DNA are elevated in cystic fibrosis and associated with more severe lung dysfunction

• Main Authors: Ruchi Yadav (Author), Rachel W. Linnemann (Author), Joanne Michelle Kahlenberg (Author), S. Louis Bridges (Author), Arlene A. Stecenko (Author), Balázs Rada (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although extracellular host DNA (ecDNA) levels in CF airways were linked to airflow obstruction and recombinant DNAse therapy is beneficial for CF patients, it remains incompletely understood whether ecDNA also leads to an autoimmune response. Here we hypothesized that chronic presence of DNA in CF...