Combined TLR7/8 and TLR9 ligands potentiate the activity of a Schistosoma japonicum DNA vaccine.

• Main Authors: Xuefeng Wang (Author), Liyang Dong (Author), Hongchang Ni (Author), Sha Zhou (Author), Zhipeng Xu (Author), Jason Shih Hoellwarth (Author), Xiaojun Chen (Author), Rongbo Zhang (Author), Qiaoyun Chen (Author), Feng Liu (Author), Jun Wang (Author), Chuan Su (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Toll-like receptor (TLR) ligands have been explored as vaccine adjuvants for tumor and virus immunotherapy, but few TLR ligands affecting schistosoma vaccines have been characterized. Previously, we developed a partially protective DNA vaccine encoding the 26-kDa glutathione S-transferas...