Encapsulation of benznidazole in nanostructured lipid carriers and increased trypanocidal activity in a resistant Trypanosoma cruzi strain

• Main Authors: Flávia Lidiane Oliveira da Silva (Author), Maria Betânia de Freitas Marques (Author), Maria Irene Yoshida (Author), Wagner da Nova Mussel (Author), João Vinícios Wirbitzki da Silveira (Author), Poliana Ribeiro Barroso (Author), Kelly Cristina Kato (Author), Helen Rodrigues Martins (Author), Guilherme Carneiro (Author)
• Format: Book
• Published: Universidade de São Paulo, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Chagas disease is a neglected parasitic disease caused by Trypanosoma cruzi, whose treatment has remained unsatisfactory for over 50 years, given that it is limited to two drugs. Benznidazole (BZN) is an efficient antichagasic drug used as the first choice, although its poor water-solubilit...