Understanding the Monoclonal Antibody Disposition after Subcutaneous Administration using a Minimal Physiologically based Pharmacokinetic Model

Purpose: Monoclonal antibodies (mAbs) are commonly administered by subcutaneous (SC) route. However, bioavailability is often reduced after SC administration. In addition, the sequential transfer of mAbs through the SC tissue and lymphatic system is not completely understood. Therefore, major object...

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Main Authors: Ninad Varkhede (Author), Laird Forrest (Author)
Format: Book
Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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