Natural Compounds as Non-Nucleoside Inhibitors of Zika Virus Polymerase through Integration of In Silico and In Vitro Approaches

• Main Authors: Paulo Ricardo Pimenta da Silva Ramos (Author), Melina Mottin (Author), Caroline Sprengel Lima (Author), Letícia R. Assis (Author), Ketllyn Zagato de Oliveira (Author), Nathalya Cristina de Moraes Roso Mesquita (Author), Natasha Marques Cassani (Author), Igor Andrade Santos (Author), Joyce Villa Verde Bastos Borba (Author), Vinícius Alexandre Fiaia Costa (Author), Bruno Junior Neves (Author), Rafael Victorio Carvalho Guido (Author), Glaucius Oliva (Author), Ana Carolina Gomes Jardim (Author), Luis Octávio Regasini (Author), Carolina Horta Andrade (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although the past epidemic of Zika virus (ZIKV) resulted in severe neurological consequences for infected infants and adults, there are still no approved drugs to treat ZIKV infection. In this study, we applied computational approaches to screen an in-house database of 77 natural and semi-synthetic...