Comparison of pharmacokinetics and safety between CE-fosphenytoin sodium, fosphenytoin sodium, and phenytoin sodium after intravenous and intramuscular administration in healthy volunteers

• Main Authors: Xiaojiao Li (Author), Min Wu (Author), Jixuan Sun (Author), Weili Jin (Author), Lei Han (Author), Jia Xu (Author), Jingrui Liu (Author), Hong Zhang (Author), Jing Wang (Author), Daidi Wang (Author), Hanyi Zhang (Author), Qing Zhang (Author), Nini Liu (Author), Yanhua Ding (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Captisol®-enabled-fosphenytoin sodium (CE-fosphenytoin sodium) injection is a modified formulation of fosphenytoin sodium.Objective: We aim to compare the intravenous and intramuscular bioavailability and safety between CE-fosphenytoin sodium, fosphenytoin sodium (Cerebyx®), and phenytoi...