Skin Delivery of siRNA Using Sponge Spicules in Combination with Cationic Flexible Liposomes

• Main Authors: XueJiao Liang (Author), JiaLiang Zhang (Author), HuiLong Ou (Author), Jun Chen (Author), Samir Mitragotri (Author), Ming Chen (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We report the topical administration of sponge Haliclona sp. Spicules (SHS) combined with cationic flexible liposomes (CFL) to increase the delivery of small interfering RNA (siRNA) into viable skin cells in vitro and in vivo. SHS can be applied topically as novel microneedles to overcome skin barri...