Developing a mechanistic understanding of the nonlinear pharmacokinetics of letermovir and prospective drug interaction with everolimus using physiological‐based pharmacokinetic modeling

• Main Authors: Karsten Menzel (Author), Yuhsin Kuo (Author), Dapeng Chen (Author), Georgy Hartmann (Author), Ying‐Hong Wang (Author), Carolyn R. Cho (Author), Jacqueline B. McCrea (Author), Kazuhiko Asari (Author)
• Format: Book
• Published: Wiley, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Letermovir is approved for use in cytomegalovirus‐seropositive hematopoietic stem cell transplant recipients and is investigated in other transplant settings. Nonlinear pharmacokinetics (PKs) were observed in clinical studies after intravenous and oral dosing across a wide dose range, inclu...