Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice

• Váldodahkkit: Mikko Karpale (Dahkki), Outi Kummu (Dahkki), Olli Kärkkäinen (Dahkki), Marko Lehtonen (Dahkki), Juha Näpänkangas (Dahkki), Uta M. Herfurth (Dahkki), Albert Braeuning (Dahkki), Jaana Rysä (Dahkki), Jukka Hakkola (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2023-10-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Objective: Both obesity and exposure to chemicals may induce non-alcoholic fatty liver disease (NAFLD). Pregnane X Receptor (PXR) is a central target of metabolism disrupting chemicals and disturbs hepatic glucose and lipid metabolism. We hypothesized that the metabolic consequences of PXR activatio...