Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice

• Main Authors: Mikko Karpale (Author), Outi Kummu (Author), Olli Kärkkäinen (Author), Marko Lehtonen (Author), Juha Näpänkangas (Author), Uta M. Herfurth (Author), Albert Braeuning (Author), Jaana Rysä (Author), Jukka Hakkola (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Both obesity and exposure to chemicals may induce non-alcoholic fatty liver disease (NAFLD). Pregnane X Receptor (PXR) is a central target of metabolism disrupting chemicals and disturbs hepatic glucose and lipid metabolism. We hypothesized that the metabolic consequences of PXR activatio...