Effects of Sulfaphenazole Derivatives on Cardiac Ischemia-Reperfusion Injury: Association of Cytochrome P450 Activity and Infarct Size

• Hoofdauteurs: Yasuhiro Ishihara (Auteur), Masaya Sekine (Auteur), Ai Hamaguchi (Auteur), Yusuke Kobayashi (Auteur), Takashi Harayama (Auteur), Mikio Nakazawa (Auteur), Norio Shimamoto (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2010-01-01T00:00:00Z.
• Onderwerpen: article
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Cardiac ischemia-reperfusion injury is evoked by reactive oxygen species (ROS). We previously reported that sulfaphenazole (SPZ) attenuated cardiac ROS levels and ischemia-reperfusion injury in rats. SPZ has distinct two actions: a) elimination of ROS and b) inhibition of cytochrome P450 (CYP) that...