Effects of Sulfaphenazole Derivatives on Cardiac Ischemia-Reperfusion Injury: Association of Cytochrome P450 Activity and Infarct Size

Effects of Sulfaphenazole Derivatives on Cardiac Ischemia-Reperfusion Injury: Association of Cytochrome P450 Activity and Infarct Size

Cardiac ischemia-reperfusion injury is evoked by reactive oxygen species (ROS). We previously reported that sulfaphenazole (SPZ) attenuated cardiac ROS levels and ischemia-reperfusion injury in rats. SPZ has distinct two actions: a) elimination of ROS and b) inhibition of cytochrome P450 (CYP) that...

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Main Authors: Yasuhiro Ishihara (Author), Masaya Sekine (Author), Ai Hamaguchi (Author), Yusuke Kobayashi (Author), Takashi Harayama (Author), Mikio Nakazawa (Author), Norio Shimamoto (Author)
Format: Book
Published: Elsevier, 2010-01-01T00:00:00Z.
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