Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses

• Main Authors: Li Yin (Author), Enming Zhang (Author), Tianqi Mao (Author), Yifan Zhu (Author), Shurui Ni (Author), Yehong Li (Author), Chunxiao Liu (Author), Yafei Fang (Author), Kexin Ni (Author), Yuhe Lu (Author), Huanqiu Li (Author), Mengze Zhou (Author), Qinghua Hu (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purinergic signaling plays a causal role in the modulation of immune inflammatory response in the course of psoriasis, but its regulatory mechanism remains unclear. As a member of purinoceptors, P2Y6R mainly distributed in macrophages was significantly up-expressed in skin lesions from patients with...