Tumor Necrosis Factor Is a Therapeutic Target for Immunological Unbalance and Cardiac Abnormalities in Chronic Experimental Chagas' Heart Disease

• Main Authors: Isabela Resende Pereira (Author), Glaucia Vilar-Pereira (Author), Andrea Alice Silva (Author), Otacilio Cruz Moreira (Author), Constança Britto (Author), Ellen Diana Marinho Sarmento (Author), Joseli Lannes-Vieira (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Chagas disease (CD) is characterized by parasite persistence and immunological unbalance favoring systemic inflammatory profile. Chronic chagasic cardiomyopathy, the main manifestation of CD, occurs in a TNF-enriched milieu and frequently progresses to heart failure. Aim of the Study. To...