Genetic Polymorphisms of TYMS, MTHFR, ATIC, MTR, and MTRR Are Related to the Outcome of Methotrexate Therapy for Rheumatoid Arthritis in a Chinese Population

• Main Authors: Shuang Lv (Author), HuiZhen Fan (Author), Jiang Li (Author), Hui Yang (Author), Jing Huang (Author), XiaoMing Shu (Author), Lu Zhang (Author), Yuan Xu (Author), Xiaoya Li (Author), Jieyu Zuo (Author), Cheng Xiao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Analysis of the relationship between single nucleotide polymorphisms (SNPs) and outcomes of methotrexate (MTX) therapy for rheumatoid arthritis (RA) in China.Materials and Methods: TYMS 28 bp VNTR (rs34743033), MTHFR [677C>T (rs1801133) and 1298A>C (rs1801131)], ATIC 347C>G (rs23...