QbD-Based Development and Evaluation of Pazopanib Hydrochloride Extrudates Prepared by Hot-Melt Extrusion Technique: In Vitro and In Vivo Evaluation

• Main Authors: Amit Gupta (Author), Rashmi Dahima (Author), Sunil K. Panda (Author), Annie Gupta (Author), Gaurav Deep Singh (Author), Tanveer A. Wani (Author), Afzal Hussain (Author), Devashish Rathore (Author)
• Format: Book
• Published: MDPI AG, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Pazopanib hydrochloride (PZB) is a protein kinase inhibitor approved by the United States Food and Drug Administration and European agencies for the treatment of renal cell carcinoma and other renal malignancies. However, it exhibits poor aqueous solubility and inconsistent oral drug abs...