Activation-induced cell death of dendritic cells is dependent on sphingosine kinase 1

• Auteurs principaux: Anja eSchwiebs (Auteur), Olga eFriesen (Auteur), Elisabeth eKatzy (Auteur), Nerea eFerreirós Bouzas (Auteur), Josef M Pfeilschifter (Auteur), Heinfried H. Radeke (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2016-04-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Sphingosine 1-phosphate (S1P) is an immune modulatory lipid mediator and has been implicated in numerous pathophysiological processes. S1P is produced by sphingosine kinase 1 (Sphk1) and Sphk2. Dendritic cells (DCs) are central for the direction of immune responses and crucially involved in autoimmu...