Primaquine Diphosphate, a Known Antimalarial Drug, Blocks Vascular Leakage Acting Through Junction Stabilization

• Ngā kaituhi matua: Minyoung Noh (Author), Haiying Zhang (Author), Hyejeong Kim (Author), Songyi Park (Author), Young-Myeong Kim (Author), Young-Guen Kwon (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Endothelial barrier integrity is important for vascular homeostasis, and hyperpermeability participates in the progression of many pathological states, such as diabetic retinopathy, ischemic stroke, chronic bowel disease, and inflammatory disease. Here, using drug repositioning, we discovered that p...