NAC and DTT promote TGF-β1 monomer formation: demonstration of competitive binding

• Main Authors: Frambach Gwyn (Author), Hunter Melissa (Author), Montague Christine R (Author), Lichtenberger Frank J (Author), Marsh Clay B (Author)
• Format: Book
• Published: BMC, 2006-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>TGF-β plays an important role in the genesis and progression of pulmonary fibrosis. We sought to determine the role of mononuclear phagocytes in the activation of TGF-β and found that freshly isolated peripheral blood monocytes spontaneously released TGF-β. Stimu...