Chemical modification of uridine modulates mRNA-mediated proinflammatory and antiviral response in primary human macrophages

In vitro transcribed (IVT)-mRNA has been accepted as a promising therapeutic modality. Advances in facile and rapid production technologies make IVT-mRNA an appealing alternative to protein- or virus-based medicines. Robust expression levels, lack of genotoxicity, and their manageable immunogenicity...

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Main Authors: Hanieh Moradian (Author), Toralf Roch (Author), Larissa Anthofer (Author), Andreas Lendlein (Author), Manfred Gossen (Author)
Format: Book
Published: Elsevier, 2022-03-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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