Chemical modification of uridine modulates mRNA-mediated proinflammatory and antiviral response in primary human macrophages

• Asıl Yazarlar: Hanieh Moradian (Yazar), Toralf Roch (Yazar), Larissa Anthofer (Yazar), Andreas Lendlein (Yazar), Manfred Gossen (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2022-03-01T00:00:00Z.
• Konular: article
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In vitro transcribed (IVT)-mRNA has been accepted as a promising therapeutic modality. Advances in facile and rapid production technologies make IVT-mRNA an appealing alternative to protein- or virus-based medicines. Robust expression levels, lack of genotoxicity, and their manageable immunogenicity...