Targeting metabolic vulnerability in mitochondria conquers MEK inhibitor resistance in KRAS-mutant lung cancer

• Main Authors: Juanjuan Feng (Author), Zhengke Lian (Author), Xinting Xia (Author), Yue Lu (Author), Kewen Hu (Author), Yunpeng Zhang (Author), Yanan Liu (Author), Longmiao Hu (Author), Kun Yuan (Author), Zhenliang Sun (Author), Xiufeng Pang (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MEK is a canonical effector of mutant KRAS; however, MEK inhibitors fail to yield satisfactory clinical outcomes in KRAS-mutant cancers. Here, we identified mitochondrial oxidative phosphorylation (OXPHOS) induction as a profound metabolic alteration to confer KRAS-mutant non-small cell lung cancer...