Targeted suicide gene therapy for liver cancer based on ribozyme-mediated RNA replacement through post-transcriptional regulation

• Main Authors: Seung Ryul Han (Author), Chang Ho Lee (Author), Ji Young Im (Author), Ju Hyun Kim (Author), Ji Hyun Kim (Author), Sung Jin Kim (Author), Young Woo Cho (Author), Eunkyung Kim (Author), Youngah Kim (Author), Ji-Ho Ryu (Author), Mi Ha Ju (Author), Jin Sook Jeong (Author), Seong-Wook Lee (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatocellular carcinoma (HCC) has high fatality rate and limited therapeutic options. Here, we propose a new anti-HCC approach with high cancer-selectivity and efficient anticancer effects, based on adenovirus-mediated Tetrahymena group I trans-splicing ribozymes specifically inducing targeted suic...