PMA Induces Vaccine Adjuvant Activity by the Modulation of TLR Signaling Pathway

• Main Authors: Dool-Ri Oh (Author), Hu Won Kang (Author), Jong-Ro Kim (Author), Sunoh Kim (Author), In-Kyu Park (Author), Joon Haeng Rhee (Author), Won Keun Oh (Author), Young Ran Kim (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Toll-like receptor (TLR) ligands are being developed for use as vaccine adjuvants and as immunomodulators because of their ability to stimulate innate and adaptive immune responses. Flagellin, a TLR5 ligand, was reported to show potent mucosal vaccine adjuvant activity. To identify ligands that pote...