A novel mouse model of Duchenne muscular dystrophy carrying a multi-exonic Dmd deletion exhibits progressive muscular dystrophy and early-onset cardiomyopathy

• Main Authors: Tatianna Wai Ying Wong (Author), Abdalla Ahmed (Author), Grace Yang (Author), Eleonora Maino (Author), Sydney Steiman (Author), Elzbieta Hyatt (Author), Parry Chan (Author), Kyle Lindsay (Author), Nicole Wong (Author), Diane Golebiowski (Author), Joel Schneider (Author), Paul Delgado-Olguín (Author), Evgueni A. Ivakine (Author), Ronald D. Cohn (Author)
• Format: Book
• Published: The Company of Biologists, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Duchenne muscular dystrophy (DMD) is a life-threatening neuromuscular disease caused by the lack of dystrophin, resulting in progressive muscle wasting and locomotor dysfunctions. By adulthood, almost all patients also develop cardiomyopathy, which is the primary cause of death in DMD. Although ther...