mRNA vaccine trafficking and resulting protein expression after intramuscular administration

• Main Authors: Kimberly J. Hassett (Author), Ivana Liric Rajlic (Author), Kapil Bahl (Author), Rebecca White (Author), Kristen Cowens (Author), Eric Jacquinet (Author), Kristine E. Burke (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mRNA vaccine route from injection site to critical immunologic tissues, as well as the localization of protein antigen following intramuscular (i.m.) administration, is crucial to generating an effective immune response. Here, we quantified mRNA at the injection site, lymph nodes, and in select...