The NADPH Oxidase Inhibitor, Mitoapocynin, Mitigates DFP-Induced Reactive Astrogliosis in a Rat Model of Organophosphate Neurotoxicity

• Main Authors: Christina Meyer (Author), Elizabeth Grego (Author), Suraj S. Vasanthi (Author), Nikhil S. Rao (Author), Nyzil Massey (Author), Claire Holtkamp (Author), Joselyn Huss (Author), Lucas Showman (Author), Balaji Narasimhan (Author), Thimmasettappa Thippeswamy (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NADPH oxidase (NOX) is a primary mediator of superoxides, which promote oxidative stress, neurodegeneration, and neuroinflammation after diisopropylfluorophosphate (DFP) intoxication. Although orally administered mitoapocynin (MPO, 10 mg/kg), a mitochondrial-targeted NOX inhibitor, reduced oxidative...