Harnessing adrenergic blockade in stress-promoted TNBC in vitro and solid tumor in vivo: disrupting HIF-1α and GSK-3β/β-catenin driven resistance to doxorubicin

• Main Authors: Yasmeen Attia (Author), Andrew Hakeem (Author), Rawda Samir (Author), Aya Mohammed (Author), Abdullrahman Elsayed (Author), Alaa Khallaf (Author), Eman Essam (Author), Hossameldeen Amin (Author), Sarah Abdullah (Author), Salwan Hikmat (Author), Tarek Hossam (Author), Ziad Mohamed (Author), Ziad Aboelmagd (Author), Olfat Hammam (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sympathetic activation triggered by chronic stress afflicting cancer survivors is an emerging modulator of tumorigenesis. Adrenergic blockade was previously associated with improving response to doxorubicin (DOX) in triple-negative breast cancer (TNBC), yet the precise underlying mechanisms remain o...