The Fate of Oxidative Strand Breaks in Mitochondrial DNA

• Main Authors: Genevieve Trombly (Author), Afaf Milad Said (Author), Alexei P. Kudin (Author), Viktoriya Peeva (Author), Janine Altmüller (Author), Kerstin Becker (Author), Karl Köhrer (Author), Gábor Zsurka (Author), Wolfram S. Kunz (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial DNA (mtDNA) is particularly vulnerable to somatic mutagenesis. Potential mechanisms include DNA polymerase γ (POLG) errors and the effects of mutagens, such as reactive oxygen species. Here, we studied the effects of transient hydrogen peroxide (H₂O<sub>2&l...