The Fate of Oxidative Strand Breaks in Mitochondrial DNA
Mitochondrial DNA (mtDNA) is particularly vulnerable to somatic mutagenesis. Potential mechanisms include DNA polymerase γ (POLG) errors and the effects of mutagens, such as reactive oxygen species. Here, we studied the effects of transient hydrogen peroxide (H<sub>2</sub>O<sub>2&l...
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