The Fate of Oxidative Strand Breaks in Mitochondrial DNA

• Príomhchruthaitheoirí: Genevieve Trombly (Údar), Afaf Milad Said (Údar), Alexei P. Kudin (Údar), Viktoriya Peeva (Údar), Janine Altmüller (Údar), Kerstin Becker (Údar), Karl Köhrer (Údar), Gábor Zsurka (Údar), Wolfram S. Kunz (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: MDPI AG, 2023-05-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Mitochondrial DNA (mtDNA) is particularly vulnerable to somatic mutagenesis. Potential mechanisms include DNA polymerase γ (POLG) errors and the effects of mutagens, such as reactive oxygen species. Here, we studied the effects of transient hydrogen peroxide (H₂O<sub>2&l...