Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice

• Main Authors: Dionysios V. Chartoumpekis (Author), Dushani L. Palliyaguru (Author), Nobunao Wakabayashi (Author), Nicholas K.H. Khoo (Author), Gabriele Schoiswohl (Author), Robert M. O'Doherty (Author), Thomas W. Kensler (Author)
• Format: Book
• Published: Elsevier, 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The Notch family of intermembrane receptors is highly conserved across species and is involved in cell fate and lineage control. Previous in vitro studies have shown that Notch may inhibit adipogenesis. Here we describe the role of Notch in adipose tissue by employing an in vivo murine mo...