Dupilumab Reduces Urticaria Activity, Itch, and Hives in Patients with Chronic Spontaneous Urticaria Regardless of Baseline Serum Immunoglobulin E Levels

• Main Authors: Marcus Maurer (Author), Thomas B. Casale (Author), Sarbjit S. Saini (Author), Moshe Ben-Shoshan (Author), Elizabeth Laws (Author), Jennifer Maloney (Author), Deborah Bauer (Author), Allen Radin (Author), Melanie Makhija (Author)
• Format: Book
• Published: Adis, Springer Healthcare, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Introduction In chronic spontaneous urticaria (CSU), interleukin (IL)-4 and IL-13 may promote mast cell activation directly via IL-4 receptor expression, or indirectly via upregulated immunoglobulin E (IgE) production. Dupilumab significantly improved CSU signs and symptoms in the phase 3,...