Effects of Ultramicronized <i>N</i>-Palmitoylethanolamine Supplementation on Tramadol and Oxycodone Analgesia and Tolerance Prevention

• Main Authors: Laura Micheli (Author), Elena Lucarini (Author), Alessandra Toti (Author), Valentina Ferrara (Author), Clara Ciampi (Author), Carmen Parisio (Author), Gianluca Bartolucci (Author), Lorenzo Di Cesare Mannelli (Author), Carla Ghelardini (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic pain management requires increasing doses of opioids, the milestone of painkillers, which may result in the onset of tolerance with exacerbated side effects. Maintaining stable analgesia with low doses of opioids is thus imperative. <i>N</i>-palmitoylethanolamine (PEA) is an endo...