AAVS1‐targeted, stable expression of ChR2 in human brain organoids for consistent optogenetic control

• Asıl Yazarlar: Soojung Hong (Yazar), Juhee Lee (Yazar), Yunhee Kim (Yazar), Eunjee Kim (Yazar), Kunyoo Shin (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2024-11-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Self‐organizing brain organoids provide a promising tool for studying human development and disease. Here we created human forebrain organoids with stable and homogeneous expression of channelrhodopsin‐2 (ChR2) by generating AAVS1 safe harbor locus‐targeted, ChR2 knocked‐in human pluripoten...