IL-1β and IL-6 modulate apolipoprotein E gene expression in rat hepatocyte primary culture

• Päätekijät: Agnes Ribeiro (Tekijä), Marise Mangeney (Tekijä), Isabelle Bernard (Tekijä), Jean Chambaz (Tekijä), Francisco Delers (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Hindawi Limited, 1992-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Incubation of rat hepatocytes in primary culture with IL-1β at a concentration of 2.5 units/ml resulted in an increase (+80%) in the amount of apoE mRNA without any effect upon apoE synthesis. IL-6 at a low concentration (10 units/ml) induced a decrease (−35%) in the amount of apoE mRNA, but increas...