IL-1β and IL-6 modulate apolipoprotein E gene expression in rat hepatocyte primary culture
Incubation of rat hepatocytes in primary culture with IL-1β at a concentration of 2.5 units/ml resulted in an increase (+80%) in the amount of apoE mRNA without any effect upon apoE synthesis. IL-6 at a low concentration (10 units/ml) induced a decrease (−35%) in the amount of apoE mRNA, but increas...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
Hindawi Limited,
1992-01-01T00:00:00Z.
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| Summary: | Incubation of rat hepatocytes in primary culture with IL-1β at a concentration of 2.5 units/ml resulted in an increase (+80%) in the amount of apoE mRNA without any effect upon apoE synthesis. IL-6 at a low concentration (10 units/ml) induced a decrease (−35%) in the amount of apoE mRNA, but increased apoE synthesis (+28%). No effect was observed with higher concentrations of IL-1β (10 units/ml) or IL-6 (100 units/ml). These results suggest that inflammatory cytokines IL-1β and IL-6 modulate the expression of apoE gene in cultured rat hepatocytes, at a concentration that does not induce the acute phase response. |
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| Item Description: | 0962-9351 1466-1861 10.1155/S0962935192000498 |