IL-1β and IL-6 modulate apolipoprotein E gene expression in rat hepatocyte primary culture

• Auteurs principaux: Agnes Ribeiro (Auteur), Marise Mangeney (Auteur), Isabelle Bernard (Auteur), Jean Chambaz (Auteur), Francisco Delers (Auteur)
• Format: Livre
• Publié: Hindawi Limited, 1992-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Incubation of rat hepatocytes in primary culture with IL-1β at a concentration of 2.5 units/ml resulted in an increase (+80%) in the amount of apoE mRNA without any effect upon apoE synthesis. IL-6 at a low concentration (10 units/ml) induced a decrease (−35%) in the amount of apoE mRNA, but increas...