Synthesis and antiviral activities of a novel class of thioflavone and flavonoid analogues

• Main Authors: Dajun Zhang (Author), Xingyue Ji (Author), Rongmei Gao (Author), Huiqiang Wang (Author), Shuai Meng (Author), Zhaojin Zhong (Author), Yuhuan Li (Author), Jiandong Jiang (Author), Zhuorong Li (Author)
• Format: Book
• Published: Elsevier, 2012-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel class of thioflavone and flavonoid derivatives has been prepared and their antiviral activities against enterovirus 71 (EV71) and the coxsackievirus B3 (CVB3) and B6 (CVB6) were evaluated. Compounds 7d and 9b showed potent antiviral activities against EV71 with IC50 values of 8.27 and 5.48 μ...