Inducible miR-1224 silences cerebrovascular Serpine1 and restores blood flow to the stroke-affected site of the brain

• Main Authors: Ravichand Palakurti (Author), Nirupam Biswas (Author), Sashwati Roy (Author), Surya C. Gnyawali (Author), Mithun Sinha (Author), Kanhaiya Singh (Author), Subhadip Ghatak (Author), Chandan K. Sen (Author), Savita Khanna (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The α-tocotrienol (TCT) form of natural vitamin E is more potent than the better known α-tocopherol against stroke. Angiographic studies of canine stroke have revealed beneficial cerebrovascular effects of TCT. This work seeks to understand the molecular basis of such effect. In mice, TCT supplement...