Acid Sphingomyelinase Promotes Endothelial Stress Response in Systemic Inflammation and Sepsis

• Main Authors: Ha-Yeun Chung (Author), Daniel C Hupe (Author), Gordon P Otto (Author), Marcel Sprenger (Author), Alexander C Bunck (Author), Michael J Dorer (Author), Clemens L Bockmeyer (Author), Hans-Peter Deigner (Author), Markus H Gräler (Author), Ralf A Claus (Author)
• Format: Book
• Published: BMC, 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The pathophysiology of sepsis involves activation of acid sphingomyelinase (SMPD1) with subsequent generation of the bioactive mediator ceramide. We herein evaluate the hypothesis that the enzyme exerts biological effects in endothelial stress response. Plasma-secreted sphingomyelinase acti...