Somatic mutations in four novel genes contribute to homologous recombination deficiency in breast cancer: a real‐world clinical tumor sequencing study

• Main Authors: Yongsheng Huang (Author), Yuntan Qiu (Author), Linxiaoxiao Ding (Author), Shuwei Ren (Author), Yuanling Jiang (Author), Jiahuan Luo (Author), Jinghua Huang (Author), Xinke Yin (Author), Sha Fu (Author), Jianli Zhao (Author), Kaishun Hu (Author), Jianwei Liao (Author)
• Format: Book
• Published: Wiley, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Breast cancers involving mutations in homologous recombination (HR) genes, most commonly BRCA1 and BRCA2 (BRCA1/2), respond well to PARP inhibitors and platinum‐based chemotherapy. However, except for these specific HR genes, it is not clear which other mutations contribute to homologous re...