Sublingual Administration of Sildenafil Oro-dispersible Film: New Profiles of Drug Tolerability and Pharmacokinetics for PDE5 Inhibitors

• Main Authors: Luca De Toni (Author), Maurizio De Rocco Ponce (Author), Erica Franceschinis (Author), Stefano Dall'Acqua (Author), Roberto Padrini (Author), Nicola Realdon (Author), Andrea Garolla (Author), Carlo Foresta (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Type 5 phosphodiesterase inhibitors (PDE5i) are efficient drugs used for treatment of erectile dysfunction (ED); however, a large discontinuation rate due to major side effects is reported. The aim of this study was to evaluate the possible improvement of sildenafil (Sild) pharmacokinetic...