Photocontrollable PROTAC molecules: Structure and mechanism of action

• Main Authors: Koravović Mladen (Author), Tasić Gordana (Author), Rmandić Milena (Author), Marković Bojan (Author)
• Format: Knjiga
• Izdano: Pharmaceutical Association of Serbia, Belgrade, Serbia, 2021-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Traditional drug discovery strategies are usually focused on occupancy of binding sites that directly affect functions of proteins. Hence, proteins that lack such binding sites are generally considered pharmacologically intractable. Modulators of protein activity, especially inhibitors, must be appl...