Spiro heterocycles bearing piperidine moiety as potential scaffold for antileishmanial activity: synthesis, biological evaluation, and in silico studies

• Main Authors: Mounir A. A. Mohamed (Author), Asmaa M. Kadry (Author), Salma A. Bekhit (Author), Mohammed A. S. Abourehab (Author), Kikuko Amagase (Author), Tamer M. Ibrahim (Author), Ahmed M. M. El-Saghier (Author), Adnan A. Bekhit (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

New spiro-piperidine derivatives were synthesised via the eco-friendly ionic liquids in a one-pot fashion. The in vitro antileishmanial activity against Leishmania major promastigote and amastigote forms highlighted promising antileishmanial activity for most of the derivatives, with superior activi...