Effect of Sophocarpine on the Pharmacokinetics of Umbralisib in Rat Plasma Using a Novel UPLC-MS/MS Method

• Autors principals: Qinghua Weng (Autor), Xia Lan (Autor), Yingjie Wang (Autor), Chen Fan (Autor), Ren-ai Xu (Autor), Pengzhao Zhang (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Umbralisib is a dual inhibitor of phosphatidylinositol 3-kinase delta (PI3Kδ) and casein kinase 1 epsilon (CK1ε) for treating marginal zone lymphoma (MZL) and follicular lymphoma (FL). This study aimed to develop a fast and stable ultra performance liquid chromatography tandem mass spectrometry (UPL...