Pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs as possible candidates against neglected tropical diseases (NTDs): identification of hit compounds towards development of potential treatment of Leishmania donovani

• Main Authors: Ahmed H. E. Hassan (Author), Trong-Nhat Phan (Author), Seolmin Yoon (Author), Cheol Jung Lee (Author), Hye Rim Jeon (Author), Seung-Hwan Kim (Author), Joo Hwan No (Author), Yong Sup Lee (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A rational-based process was adopted for repurposing pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs bearing variable acyl chains, different stereochemical configuration and/or positional relationships. Structural features were highly influential on activity. Amongst, enantiomer 1e havi...