Pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs as possible candidates against neglected tropical diseases (NTDs): identification of hit compounds towards development of potential treatment of Leishmania donovani

• Príomhchruthaitheoirí: Ahmed H. E. Hassan (Údar), Trong-Nhat Phan (Údar), Seolmin Yoon (Údar), Cheol Jung Lee (Údar), Hye Rim Jeon (Údar), Seung-Hwan Kim (Údar), Joo Hwan No (Údar), Yong Sup Lee (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

A rational-based process was adopted for repurposing pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs bearing variable acyl chains, different stereochemical configuration and/or positional relationships. Structural features were highly influential on activity. Amongst, enantiomer 1e havi...