Pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs as possible candidates against neglected tropical diseases (NTDs): identification of hit compounds towards development of potential treatment of Leishmania donovani

• मुख्य लेखकों: Ahmed H. E. Hassan (लेखक), Trong-Nhat Phan (लेखक), Seolmin Yoon (लेखक), Cheol Jung Lee (लेखक), Hye Rim Jeon (लेखक), Seung-Hwan Kim (लेखक), Joo Hwan No (लेखक), Yong Sup Lee (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

A rational-based process was adopted for repurposing pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs bearing variable acyl chains, different stereochemical configuration and/or positional relationships. Structural features were highly influential on activity. Amongst, enantiomer 1e havi...