Brain-Selective Estrogen Therapy Prevents Androgen Deprivation-Associated Hot Flushes in a Rat Model

• Main Authors: Istvan Merchenthaler (Author), Malcolm Lane (Author), Christina Stennett (Author), Min Zhan (Author), Vien Nguyen (Author), Katalin Prokai-Tatrai (Author), Laszlo Prokai (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hot flushes are best-known for affecting menopausal women, but men who undergo life-saving castration due to androgen-sensitive prostate cancer also suffer from these vasomotor symptoms. Estrogen deficiency in these patients is a direct consequence of androgen deprivation, because estrogens (notably...